Biomolecular Resource Facility

Mission

 

To assist investigators by providing access to cutting-edge technology, methodology and expertise in order to accurately identify, characterize and quantify molecular species.

Overview of Services

Molecular Weight Determination: from small molecules to proteins. Multiple options are available MALDI-TOF MS, infusion ESI, or LC-MS. For protein analysis, ammonium salt buffers are preferred and detergents must be avoided.
 
Protein Identification: Proteins can be identified either from solutions or gels by using a protease, typically trypsin, and performing MS or MS/MS. Proteins can be identified as pure, protein complexes, or complex mixtures such as cell extracts.
 
Posttranslational Modification Analysis: PTMs such as phosphorylation, glycosylation, acetylation, etc. can be identified directly or preferably through enrichment strategies. 
 
Protein/Peptide Quantitation: SWATH, Label-free, isobarically labelled (iTRAQ, TMT), or SILAC labeled work flows are all supported.
 
Directed Proteomics: Selected reaction monitoring of peptides or small molecules is supported on our Sciex 6500 Qtrap.
 
Data Analysis: For bioinformatics beyond MASCOT or Sequest output, i.e. pathway analysis, statistical analysis, quantitation.
 
Sample Processing: Capabilities for abundant protein depletion, offline LC fractionation, 1- and 2-D gel electrophoresis, capillary electrophoresis, and PTM enrichment are available.
 
Please inquire for more information about any of the above services.

Leadership

Director of Mass Spectrometry and Core Services
William Russell Ph.D
1.106 Libbie Moody Thompson Basic Science Building
301 University Boulevard
Galveston, TX 77555-3579
Email: bill.russell@utmb.edu
(409) 772-3579
 
 

Personnel

Xuemei Luo, Ph.D
Email: xueluo@utmb.edu
(409) 772-8085
 
Zheng W, Ph.D 
Email: zhewu@utmb.edu
(409) 772-8085
 
Cheryl Lichti, Ph.D
Email: cflichti@utmb.edu
(409) 772-8085
 
Location and hours of operation:
Open 8-5:30 M-F
301 University Boulevard
Galveston, TX 77555-3579
 
UTMB Faculty Oversight:
Mariano Garcia-Blanco MD Ph.D
Alan Brasier MD
Alex Kurosky Ph.D

Contacts

Name Role Phone Email Location
William Russell, Ph.D
Director of Mass Spectrometry and Core Services
 
(409) 772-3579
 
bill.russell@utmb.edu
 
1.106 Libbie Moody Thompson Basic Science Bldg.
 
Xuemei Luo, Ph.D
Personnel
 
(409)772-6338
 
xueluo@utmb.edu
 

 
Zheng Wu, Ph.D
Personnel
 
(409)772-6338
 
zhwu@utmb.edu
 

 
Cheryl Lichti, Ph.D
Personnel
 
(409)772-8085
 
cflichti@utmb.edu
 

 

Services


Search available services: View: by category alphabetically
Analysis of Images (1)
HPLC separations (3)
Imaging (1)
Isoelectric Focusing (2)
MS analysis of gel spots by robots (3)
Manual gel picking, digestion and HPLC/MS analysis (6)
Mass Spectrometry (4)
Other (3)
Protein Chemistry (2)
Proteomics Discovery (14)
SDS-PAGE (5)
Sequencing (2)
Training (3)

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